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This article will focus on Modified GRF 1-29 and Ipamorelin Blend and its involvement in extensive research.
Studies suggest Ipamorelin is a five-amino-acid peptide that has been investigated for its possible use as a manufactured analog of growth hormone (hGH). Synthetic growth hormone- releasing hormone (GHRH) analogs like modified GRF (1-29) peptide (also known as Mod GRF 1-29) have been developed. It consists of 29 amino acids and differs somewhat from native GHRH in that four amino groups are replaced with more stable groups. [i]
Researchers studying animal test models speculate the pituitary gland may be stimulated by these peptides, producing growth hormones. Additionally, scientists hypothesize these peptides seem to have synergistic effects when supplied as a blend. Research suggests they could have additional effects, including enhanced bone density, improved sleep cycle, and a significant effect on the health of the intestines and the heart.
Scientists hypothesize key to this peptide blend’s potential is that, whereas Mod GRF 1-29 may have longer-lasting effects, Ipamorelin seems to be a fast-acting peptide with a short half-life. Therefore, when combined, the effects of Ipamorelin may start sooner, and the effects of Mod GRF 1-29 peptide can start as soon as it begins to taper down, possibly resulting in more sustained action, researchers suggest.
Studies suggest growth hormone secretagogues (GSHs) include Mod GRF 1-29 and Ipamorelin peptides. Growth hormone secretagogues (GSHs) and growth hormone-releasing peptides (GHRPs) were evaluated in a clinical context in one study [ii]. Several test subjects were observed for physiological responses after being exposed to GSHs. This comprehensive investigation suggested these peptides appeared to stimulate hunger and improve lean mass in older subjects, possibly boosting growth rates in younger subjects. These peptides were suggested to enhance sleep quality, increase lean body mass, and decrease bone turnover in animal models of obesity. The findings of this research suggested these peptides "may increase lean body mass, reduce fat mass, increase exercise tolerance and maximum oxygen uptake, enhance muscle strength, and improve linear growth." Since long-term research findings on GH presentation have been inconclusive, researchers have established stringent standards for using this hormone and it is strictly available for laboratory research purposes only. [ii]
These growth hormone secretagogues were first introduced to the pituitary glands of awake, anesthetized rats and pigs in a 1998 study [iii]. All three investigations suggested that these peptides may bind to GHRP-like receptors, suggesting they are agonists of these receptors and contribute to increased growth hormone secretion. It suggested that Ipamorelin and Modified GRF 1-29 peptides appeared to display selectivity towards growth hormones solely. Still, other growth hormone secretagogues also seemed to stimulate elevated levels of other hormones, including cortisol and ACTH.
One clinical trial from 1999 [iv] involved 8 male subjects in testing various quantities of growth hormone secretagogues. Up to two hours passed when the concentrations were raised at 15-minute intervals. The findings suggested growth hormone levels appeared to increase substantially during the trial, as measured by post-study measurements.
Multiple high-quality studies [v] have been performed on test models exhibiting growth hormone deficiencies since 2001. So far, research seems to suggest that:
“The predominant site of action of GHSs on GH secretion has not been established,” writes Rogerio G Gondo et al. Studies suggest GHSs probably function at both the hypothalamus and the pituitary since receptors for GHSs have also been found there (24,) (26). [v] Research suggests these peptides may also stimulate hunger, enhance heart tone, and regulate sleep, in addition to their role in triggering the production of growth hormones. In another study[vi], growth hormone secretagogues were given to six test subjects with a growth hormone shortage over eight months. The release of growth hormone at regular intervals was tracked in all models. The study’s findings suggested these subjects seemed to show an exponential increase in growth hormone levels within two months of peptide presence.
In this pilot study,[vii] experimental rats were given GHRH peptide analogs such as Modified GRF 1-29 peptide and then studied. Studies suggest myocardial infarction subjects may be helped by this peptide’s potential to increase heart rate and enhance blood pumping capabilities. Researchers speculated that the peptide could improve ejection fraction and promote cardiac tissue repair.
Researchers suggest some daily growth hormone releases may influence deep non-REM sleep (NREMS) [viii] in animal studies. Scientists hypothesize the NREMS cycle may be enhanced using growth hormone secretagogues such as Ipamorelin and Modified GRF 1-29 peptide. Mutant and transgenic mice with a deficiency in GHRHergic function show consistently lower NREMS. This finding is not considered to be rectified by presenting supplemental GH, as Ferenc Obal Jr et al. reported. Studies suggest sleep-wake activity throughout the daily cycle, sleep deprivation, and recovery sleep may be correlated with GHRH contents and mRNA levels in the hypothalamus. Researchers speculate GHRH may act on the hypothalamus to stimulate NREMS. Candidates for mediating GHRH’s stimulation of NREMS include GABAergic neurons in the anterior hypothalamus/preoptic region.
Further research is required to comprehensively understand the potential applications of the subject in the field of science. The utilization of Modified GRF 1-29 and Ipamorelin Blend is limited to research and educational institutions. Core Peptides is an excellent platform for authorized researchers seeking to procure peptides for their laboratory conditions. It is important to note that none of the substances discussed in this context have received approval for consumption by either humans or animals.
[i] National Center for Biotechnology Information (2023). PubChem Compound Summary for CID 91976842, CJC1295 Without DAC. https://pubchem.ncbi.nlm.nih.gov/compound/CJC1295-Without-DAC.
[ii] Sigalos, John T, and Alexander W Pastuszak. “The Safety and Efficacy of Growth Hormone Secretagogues.” Sexual medicine reviews vol. 6,1 (2018): 45-53. doi:10.1016/j.sxmr.2017.02.004 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632578/
[iii] Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH.Ipamorelin, the first selective growth hormone secretagogue.Eur J Endocrinol.1998 Nov;139(5):552-61.doi: 10.1530/eje.0.1390552.PMID: 9849822. https://pubmed.ncbi.nlm.nih.gov/9849822/
[iv] Gobburu, J.V.S., Agersø, H., Jusko, W.J. et al. Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers. Pharm Res 16, 1412–1416 (1999). https://doi.org/10.1023/A:1018955126402
[v] Roger G. Gondo, Manuel H. Aguiar-Oliveira, Cesar Y. Hayashida, Sergio PA Toledo, Neusa Abelin, Michael A. Levine, Cyril Y. Bowers, Anita HO Souza, Rossana MC Pereira, Norma L. Santos, Roberto Salvatori, Growth Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient Patients with Mutated GH-Releasing Hormone Receptor, The Journal of Clinical Endocrinology &Metabolism, Volume 86, Issue 7, July 1, 2001, Pages 3279–3283, https://doi.org/10.1210/jcem.86.7.7694
[vi] Mericq V, Cassorla F, Salazar T, Avila A, Iñiguez G, Bowers CY, Merriam GR. Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children. J Clin Endocrinol Metab. 1998 Jul;83(7):2355-60. doi: 10.1210/jcem.83.7.4969. PMID: 9661608. https://pubmed.ncbi.nlm.nih.gov/9661608/
[vii] Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M. Actions and Potential Therapeutic Applications of Growth Hormone-Releasing Hormone Agonists. Endocrinology. 2019 Jul 1;160(7):1600-1612. https://pubmed.ncbi.nlm.nih.gov/31070727/
[viii] Obal F Jr, Krueger JM. GHRH and sleep. Sleep Med Rev. 2004 Oct;8(5):367-77. doi: 10.1016/j.smrv.2004.03.005. PMID: 15336237. https://pubmed.ncbi.nlm.nih.gov/15336237/
Sermorelin The news and editorial staff of the Vacaville Reporter had no role in this post’s preparation. This is a paid advertisement and does not necessarily reflect the official policy or position of the Vacaville Reporter, its employees, or subsidiaries.